Recent Publications

For all publications, see Alyson Fournier on Google Scholar.
Underline indicates Fournier trainee

2019

Profiling the microRNA signature of the peripheral sensory ganglia in experimental autoimmune encephalomyelitis (EAE). Friedman TN, Yousuf MS, Catuneanu A, Desai M, Juzwik CA, Fournier AE, Kerr BJ. (2019). J Neuroinflammation .

microRNA dysregualtion in neurodegenerative disease: a systematic review. Juzwik CA, Drake SS, Zhang Y, Paradis-Isler N, Sylvester A, Amar-Zifkin A, Douglas C, Morquette B, Moore CS, Fournier AE. (2019). Progress in Neurobiology.

MicroRNA-223 protects neurons from degeneration in experimental autoimmune encephalomyelitis. Morquette B*, Juźwik CA*, Drake S, Charabati M, Zhang Y, Lécuyer MA, Galloway D, Dumas A., de Faria Jr O, Bueno M, Rambaldi I, Moore C, Bar-Or A, Vallieres L, Prat A, Fournier AE.(2019). Brain.

2018

Neuronal microRNA regulation in Experimental Autoimmune Encephalomyelitis. Juźwik CA, Drake S, Lécuyer MA, Johnson RM, Morquette B, Zhang Y, Charabati M, Sagan SM, Bar-Or A, Prat A, Fournier AE.(2018). Sci Rep.

The Molecular Interplay between Axon Degeneration and Regeneration. Girouard MP, Bueno M, Julian V, Drake S, Byrne AB, Fournier AE. (2018). Dev Neurobiol.

IL-1β enables CNS access to CCR2hi monocytes and the generation of pathogenic cells through GM-CSF released by CNS endothelial cells. Paré A, Mailhot B, Lévesque SA, Juzwik C, Ignatius Arokia Doss PM, Lécuyer MA, Prat A, Rangachari M, Fournier A, Lacroix S. (2018). Proc Natl Acad Sci U S A.

MT3-MMP Promotes Excitatory Synapse Formation by Promoting Nogo-66 Receptor Ectodomain Shedding. Sanz RL, Ferraro GB, Kacervosky J, Salesse C, Gowing E, Hua L, Rambaldi I, Beaubien F, Holmbeck K, Cloutier JF, Lévesque M, Murai K, Fournier AE. (2018). J Neurosci.

2017

Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidase Domain 10 (ADAM10) promotes neurite outgrowth in DRG neurons.  Sanz, R., Ferraro, G.B., Girouard, M.P., Fournier, A.E. (2017). Scientific Reports.   
 
Targeting 14-3-3 adaptor protein-protein interactions to stimulate CNS repair.  Kaplan, A., Fournier, A.E. (2017).  Neural Regeneration Research.
 
Maximizing functional axon repair in the injured CNS – lessons learned from neuronal development. Kaplan, A., Bueno, M. M., Hua, L., Fournier, A.E. (2017).  Dev Dyn. 2017 Jun 23. doi: 10.1002/dvdy.24536

Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, Banerjee SL, Antel J, Bisson N, David S, Fournier AE. Neuron. 2017 Mar 8;93(5):1082-1093.e5. doi: 10.1016/j.neuron.2017.02.018.
**Featured on cover
**Highlighted in Nature Reviews Drug Discovery
**CTV News coverage

Extracellular functions of 14-3-3 adaptor proteins. Kaplan A, Bueno M, Fournier AE. Cell Signal. 2017 Feb;31:26-30. doi: 10.1016/j.cellsig.2016.12.007.

2016

Low-cost multimodal light sheet microscopy for optically cleared tissues and living specimens. Rouger V, Alchini R, Kazarine A, Gopal AA, Girouard MP, Fournier AE, Wiseman PW. J Biomed Opt. 2016 Dec 1;21(12):126008. doi: 10.1117/1.JBO.21.12.126008.

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. Girouard MP, Pool M, Alchini R, Rambaldi I, Fournier AE. PLoS One. 2016 Dec 19;11(12):e0168641. doi: 10.1371/journal.pone.0168641.

Slitrk1 is localized to excitatory synapses and promotes their development. Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF. Sci Rep. 2016 Jun 7;6:27343. doi: 10.1038/srep27343.

Hanea ST, Shanmugalingam U, Fournier AE, Smith PD. Preparation of embryonic retinal explants to study CNS neurite growth. Exp Eye Res. 2016 Apr 9;146:304-312.

Magdesian MH, Lopez-Ayon GM, Mori M, Boudreau D, Goulet-Hanssens A, Sanz R, Miyahara Y, Barrett CJ, Fournier AE, De Koninck Y, Grütter P. Rapid Mechanically Controlled Rewiring of Neuronal Circuits. J Neurosci. 2016 Jan 20;36(3):979-87.

Antoine-Bertrand J, Duquette PM, Alchini R, Kennedy TE, Fournier AE, Lamarche-Vane N. p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance. J Biol Chem. 2016 Feb 26;291(9):4589-602.

2015

DeGeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy TE, Debant A, Cayouette M, Fournier AE, Lamarche-Vane N. Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1. J Cell Biol. 2015 Aug 31;210(5):817-32.

Kaplan A, Ong Tone S, Fournier AE (2015). Extrinsic and intrinsic regulation of axon regeneration at a crossroads. Front Mol Neurosci. 2015 Jun 16;8:27.

Leong SY, Kaplan A, Wang LC, Almazan G, Fournier AE, Antel J. Properties of human central nervous system neurons in a glia-depleted (isolated) culture system. J Neurosci Methods. 2015 Jun 18;253:142-150

Sanz R, Ferraro GB, Fournier AE (2015). IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015 Feb 13;290(7):4330-42.

2014

Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE. (2014) Collapsin Response Mediator Protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. J Biol Chem. 2014 Oct 24;289(43)30133-43.

Khazaei MR, Montcalm S, Di Polo A, Fournier AE, Durocher Y, Tone SO. (2014) Development of a Cell Permeable Competitive Antagonist of RhoA and CRMP4 binding, TAT-C4RIP, to Promote Neurite Outgrowth. J Mol Neurosci. 2015 Feb;55(2):406-15.

Kaplan, A.*, Sanz, R.*, Ferraro, G.*, Alchini, R.*, Fournier, A.E. (2014) Neurite outgrowth and growth cone collapse assays to assess neuronal responses to extracellular cues.  Methods in Molecular Biology – Axon growth and regeneration:  Methods and protocols. 2014;1162:43-56. *Equal contribution

Kaplan, A.*, Kent, C.B.*, Charron, F., Fournier, A.E. (2014) Switching Responses: Spatial and Temporal Regulators of Axon Guidance. Mol. Neurobiology. 2014 49(2):1077-86
*Equal contribution

Gordon-Weeks, P. & Fournier, A.E. (2014) Neuronal Cytoskeleton in synaptic plasticity and regeneration.  J. Neurochem. 2014 192(2):206-12.

2013

Shimada T., Fournier A.E., Yamagata K. (2013). Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration. Biomed Res Int. 2013:564534.

2012

Yam, P. T.*, Kent, C. B.*, Morin, S., Farmer, W. T., Alchini, R., Lepelletier, L., Colman, D. R., Tessier-Lavigne, M., Fournier, A. E.# & Charron, F.# (2012). 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron 76, 735-49.
*Equal contribution #Co-corresponding authors 

Pool, M., Rambaldi, I., Darlington, P. J., Wright, M. C., Fournier, A. E.* & Bar-Or, A.* (2012). Neurite outgrowth is differentially impacted by distinct immune cell subsets. Mol Cell Neurosci 49, 68-76.
*Co-corresponding authors

McKerracher L., Ferraro, G.B., Fournier, A.E.  (2012)  Rho signaling and axon regeneration.  International Review of Neurobiology.  Edited by Jeffrey L. Goldberg and Ephraim F. Trakhtenberg  105:117-40
 
McKerracher, L., Fehlings, M., Fournier, A., Ong Tone, S.  (2012).  Neuroregeneration approaches.  In: Essentials of Spinal Cord Injury, Thieme Medical Publishers Inc. NY, NY. Edited by:  Michael Fehlings, Alex Vaccaro, Maxwell Boakye, Serge Rossignol, Anthony Burns and John DiTunno.

2011

Ferraro, G. B., Morrison, C. J., Overall, C. M., Strittmatter, S. M. & Fournier, A. E. (2011). Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem 286, 31418-24.

Pool M., Rambaldi, I., Durafourt B.A., Antel J.P., Wright M.C., Bar-Or, A.*, Fournier A.E.* (2011) Myeloid lineage cells inhibit neurite outgrowth through a myosin II dependent mechanism. J. Neuroimmunology; 237 (2011) 101–105.
*Co-corresponding authors 

2010

Ong Tone S., Dayanandan B, Fournier, A.E*., Mandato, C.A.*. (2010)  GSK3 Regulates Mitotic Chromosomal Alignment through CRMP4. PLoS ONE 5(12): e14345.
*Co-corresponding authors.

Kent, C., Shimada, T., Ferraro, G., Rodriguez, S., Yam, P., Ritter, B., McPherson, P., Charron, F., Kennedy, T., Fournier, A.E. (2010)  14-3-3 proteins regulate growth cone responses through PKA. J. Neurosci. 30(42):14059-67

Thomas, R., Favell, K., Morante-Redolat, J.M., Kent, C., Wright, M., Pool, M., Daignault, K., Fournier, A.E., Pérez-Tur, J., Barker, P.A. (2010)  LGI1 is a Novel Nogo Receptor  Ligand that Blocks Myelin-based Growth Inhibition.  J. Neurosci. 30(19): 6607-6612.

Alabed, Y.Z., Pool, M., Ong Tone, S., Sutherland, C., Fournier, A.E. (2010) GSK3b regulates myelin dependent axon outgrowth inhibition through CRMP4.  J Neurosci. 30(16):5635-43

O'Connor, K.C., Lopez-Amaya, C., Gagne, D., Moore, N.H., Kennedy, J., Krupp, L., Tenembaum, S., Ness, J., Belman, A., Boiko, A., Bykova, O., Mah, J., Stoian, C., Waubant, E., Kremenchutzky, M., Ruggieri, M., Bardini, M.R., Rensel, M., Hahn, J., Weinstock-Guttman, B., Yeh, A., Farrell, K., Freedman, M., Livanainen, M., Bhan, V., Dilenge, M., Hancock, M.A., Gano, D., Fattahie, R., Kopel, L., Fournier, A.E., Hafler, D.A., Moscarello, M., Banwell, B., Bar-Or, A. (2010)  Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J. Neuroimmunol. doi:10.1016/j.jneuroim.2010.02.019