Recent Publications

Underline indicates Fournier trainee


Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidase Domain 10 (ADAM10) promotes neurite outgrowth in DRG neurons.  Sanz, R., Ferraro, G.B., Fournier, A.E. (in press) Scientific Reports.   
Targeting 14-3-3 adaptor protein-protein interactions to stimulate CNS repair. 
Kaplan, A., Fournier, A.E. (in press)  Neural Regeneration Research
Maximizing functional axon repair in the injured CNS – lessons learned from neuronal development. Kaplan, A., Bueno, M. M., Hua, L., Fournier, A.E. (2017).  Dev Dyn. 2017 Jun 23. doi: 10.1002/dvdy.24536

Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, Banerjee SL, Antel J, Bisson N, David S, Fournier AE. Neuron. 2017 Mar 8;93(5):1082-1093.e5. doi: 10.1016/j.neuron.2017.02.018.
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Highlighted in Nature Reviews Drug Discovery
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Extracellular functions of 14-3-3 adaptor proteins. Kaplan A, Bueno M, Fournier AE. Cell Signal. 2017 Feb;31:26-30. doi: 10.1016/j.cellsig.2016.12.007.


Low-cost multimodal light sheet microscopy for optically cleared tissues and living specimens. Rouger V, Alchini R, Kazarine A, Gopal AA, Girouard MP, Fournier AE, Wiseman PW. J Biomed Opt. 2016 Dec 1;21(12):126008. doi: 10.1117/1.JBO.21.12.126008.

RhoA Proteolysis Regulates the Actin Cytoskeleton in Response to Oxidative Stress. Girouard MP, Pool M, Alchini R, Rambaldi I, Fournier AE. PLoS One. 2016 Dec 19;11(12):e0168641. doi: 10.1371/journal.pone.0168641.

Slitrk1 is localized to excitatory synapses and promotes their development. Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF. Sci Rep. 2016 Jun 7;6:27343. doi: 10.1038/srep27343.

Hanea ST, Shanmugalingam U,
Fournier AE, Smith PD. Preparation of embryonic retinal explants to study CNS neurite growthExp Eye Res. 2016 Apr 9;146:304-312.

Magdesian MH, Lopez-Ayon GM, Mori M, Boudreau D, Goulet-Hanssens A, Sanz R, Miyahara Y, Barrett CJ, Fournier AE, De Koninck Y, Grütter P. Rapid Mechanically Controlled Rewiring of Neuronal CircuitsJ Neurosci. 2016 Jan 20;36(3):979-87.

Antoine-Bertrand J, Duquette PM,
Alchini R, Kennedy TE, Fournier AE, Lamarche-Vane N. p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and GuidanceJ Biol Chem. 2016 Feb 26;291(9):4589-602.


DeGeer J, Kaplan A, Mattar P, Morabito M, Stochaj U, Kennedy TE, Debant A, Cayouette M, Fournier AE, Lamarche-Vane N. Hsc70 chaperone activity underlies Trio GEF function in axon growth and guidance induced by netrin-1. J Cell Biol. 2015 Aug 31;210(5):817-32.

Kaplan A
, Ong Tone S, Fournier AE (2015). Extrinsic and intrinsic regulation of axon regeneration at a crossroads. Front Mol Neurosci. 2015 Jun 16;8:27.

Leong SY,
Kaplan A, Wang LC, Almazan G, Fournier AE, Antel J. Properties of human central nervous system neurons in a glia-depleted (isolated) culture system. J Neurosci Methods. 2015 Jun 18;253:142-150

Sanz R, Ferraro GB, Fournier AE (2015). IgLON cell adhesion molecules are shed from the cell surface of cortical neurons to promote neuronal growth. J Biol Chem. 2015 Feb 13;290(7):4330-42.


Khazaei MR, Girouard MP, Alchini R, Ong Tone S, Shimada T, Bechstedt S, Cowan M, Guillet D, Wiseman PW, Brouhard G, Cloutier JF, Fournier AE. (2014) Collapsin Response Mediator Protein 4 regulates growth cone dynamics through the actin and microtubule cytoskeleton. J Biol Chem. 2014 Oct 24;289(43)30133-43.

Khazaei MR
, Montcalm S, Di Polo A, Fournier AE, Durocher Y, Tone SO. (2014) Development of a Cell Permeable Competitive Antagonist of RhoA and CRMP4 binding, TAT-C4RIP, to Promote Neurite Outgrowth. J Mol Neurosci. 2015 Feb;55(2):406-15.

Kaplan, A.
*, Sanz, R.*, Ferraro, G.*, Alchini, R.*, Fournier, A.E. (2014) Neurite outgrowth and growth cone collapse assays to assess neuronal responses to extracellular cuesMethods in Molecular Biology – Axon growth and regeneration:  Methods and protocols. 2014;1162:43-56. *Equal contribution

Kaplan, A.*, Kent, C.B.*, Charron, F., Fournier, A.E. (2014) Switching Responses: Spatial and Temporal Regulators of Axon Guidance. Mol. Neurobiology. 2014 49(2):1077-86
*Equal contribution

Gordon-Weeks, P. &
Fournier, A.E. (2014) Neuronal Cytoskeleton in synaptic plasticity and regeneration.  J. Neurochem. 2014 192(2):206-12.


Shimada T., Fournier A.E., Yamagata K. (2013). Neuroprotective Function of 14-3-3 Proteins in Neurodegeneration. Biomed Res Int. 2013:564534.


Yam, P. T.*, Kent, C. B.*, Morin, S., Farmer, W. T., Alchini, R., Lepelletier, L., Colman, D. R., Tessier-Lavigne, M., Fournier, A. E.# & Charron, F.# (2012). 14-3-3 proteins regulate a cell-intrinsic switch from sonic hedgehog-mediated commissural axon attraction to repulsion after midline crossing. Neuron 76, 735-49.
*Equal contribution #Co-corresponding authors 

Pool, M., Rambaldi, I., Darlington, P. J., Wright, M. C., Fournier, A. E.* & Bar-Or, A.* (2012). Neurite outgrowth is differentially impacted by distinct immune cell subsets. Mol Cell Neurosci 49, 68-76.
*Co-corresponding authors

McKerracher L., Ferraro, G.B., Fournier, A.E.  (2012)  Rho signaling and axon regeneration.  International Review of Neurobiology.  Edited by Jeffrey L. Goldberg and Ephraim F. Trakhtenberg  105:117-40
McKerracher, L., Fehlings, M.,
Fournier, A., Ong Tone, S.  (2012).  Neuroregeneration approaches.  In: Essentials of Spinal Cord Injury, Thieme Medical Publishers Inc. NY, NY. Edited by:  Michael Fehlings, Alex Vaccaro, Maxwell Boakye, Serge Rossignol, Anthony Burns and John DiTunno.


Ferraro, G. B., Morrison, C. J., Overall, C. M., Strittmatter, S. M. & Fournier, A. E. (2011). Membrane-type matrix metalloproteinase-3 regulates neuronal responsiveness to myelin through Nogo-66 receptor 1 cleavage. J Biol Chem 286, 31418-24.

Pool M., Rambaldi, I., Durafourt B.A., Antel J.P., Wright M.C., Bar-Or, A.*, Fournier A.E.* (2011) Myeloid lineage cells inhibit neurite outgrowth through a myosin II dependent mechanism. J. Neuroimmunology; 237 (2011) 101–105.
*Co-corresponding authors 


Ong Tone S., Dayanandan B, Fournier, A.E*., Mandato, C.A.*. (2010)  GSK3 Regulates Mitotic Chromosomal Alignment through CRMP4. PLoS ONE 5(12): e14345.
*Co-corresponding authors.

Kent, C., Shimada, T., Ferraro, G., Rodriguez, S., Yam, P., Ritter, B., McPherson, P., Charron, F., Kennedy, T., Fournier, A.E. (2010)  14-3-3 proteins regulate growth cone responses through PKA. J. Neurosci. 30(42):14059-67

Thomas, R., Favell, K., Morante-Redolat,
J.M., Kent, C., Wright, M., Pool, M., Daignault, K., Fournier, A.E., Pérez-Tur, J., Barker, P.A. (2010)  LGI1 is a Novel Nogo Receptor  Ligand that Blocks Myelin-based Growth Inhibition.  J. Neurosci. 30(19): 6607-6612.

Alabed, Y.Z., Pool, M., Ong Tone, S., Sutherland, C., Fournier, A.E. (2010) GSK3b regulates myelin dependent axon outgrowth inhibition through CRMP4.  J Neurosci. 30(16):5635-43

O'Connor, K.C., Lopez-Amaya, C., Gagne, D., Moore, N.H., Kennedy, J., Krupp, L., Tenembaum, S., Ness, J., Belman, A., Boiko, A., Bykova, O., Mah, J., Stoian, C., Waubant, E., Kremenchutzky, M., Ruggieri, M., Bardini, M.R., Rensel, M., Hahn, J., Weinstock-Guttman, B., Yeh, A., Farrell, K., Freedman, M., Livanainen, M., Bhan, V., Dilenge, M., Hancock, M.A.,
Gano, D., Fattahie, R., Kopel, L., Fournier, A.E., Hafler, D.A., Moscarello, M., Banwell, B., Bar-Or, A. (2010)  Anti-myelin antibodies modulate clinical expression of childhood multiple sclerosis. J. Neuroimmunol. doi:10.1016/j.jneuroim.2010.02.019


Nash, M., Pribiag, H., Fournier, A.E., Jacobson, C. (2009) Central Nervous System Regeneration Inhibitors and their Intracellular Substrates.  Mol. Neurobiology DOI 10.1007/s12035-009-8083-y

Pool, M., Niino, Rambaldi, I., Robson, K., Bar-Or, A., Fournier, A.E. (2009) Myelin regulates immune cell adhesion and motility.  Exp. Neurol. 217(2):371-7

Moore SW, Correia JP, Lai Wing Sun K, Pool M,
Fournier AE, Kennedy TE. (2008) Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1.  Development. Sep;135(17):2855-64.

Costantino S,
Kent CB, Godin AG, Kennedy TE, Wiseman PW, Fournier AE. (2008)  Semi-automated quantification of filopodial dynamics.  J. Neurosci Methods.  Jun 15;171 (1) 165-73.

Pool, M., Thiemann, J., Bar-Or, A., Fournier, A.E. (2008) NeuriteTracer: A novel ImageJ plugin for automated quantification of neurite outgrowth. J Neurosci Methods, Feb 15; 168(1): 134-9.

Alabed, Y.Z., Pool, M., Ong Tone, S., Fournier, A.E. (2007) Identification of CRMP4 as a convergent regulator of axon outgrowth inhibition. J. Neurosci. 27, 1702-1711.

Darenfed, H., Dayandana, B.,
Hsieh, S. H.-K., Fournier, A.E., Mandato. C.A. (2007) Molecular Characterization of the Effects of Y-27632. Cytoskeleton and Cell Motility. 64, 97-109.

Niino, M., Bodner, C., Simard, M.-L., Alatab, S., Gano, D., Kim, H., Trigueiro, M., Racicot, D., Guérette, C., Mainville, M., Antel, J.P.,
Fournier, A.E., Grand'Maison, F., Bar-Or, A. (2006) Natalizumab Effects on Immune Cell Responses in Multiple Sclerosis: The Expected and Less Expected. Ann. Neurol. 59:748-754.

Alabed, Y.Z., Grados-Munro, E., Ferraro, G.B., Hsieh, S.H.-K., Fournier, A.E. (2006) Neuronal responses to myelin are mediated by rho kinase. J. Neurochem. 96, 1616-1625

Hsieh, S. H.-K.*, Ferraro, G.B.*, Fournier, A.E. (2006) Myelin-associated inhibitors regulate cofilin phosphorylation and neuronal inhibition through Lim kinase and Slingshot phosphatase. J. Neurosci. 26(3), 1006-1015.
*Equal contribution

Ferraro, G.B., Alabed, Y.Z., Fournier, A.E. (2004) Current Molecular Approaches to Promote CNS Regeneration. Curr Neurovasc Res 1:61-75.

Hu F, Liu, B.P., Budel, S., Liao, J., Chin, J.,
Fournier, A.E. Strittmatter, S.M. (2005)  Nogo-A Interacts with the Nogo-66 Receptor through Multiple Sites to Create an Isoform-Selective Subnanomolar Agonist.  J. Neurosci.  25, 5298-5304.
Barton, W.A., Liu, B.P., Tzvetkova, D., Jeffrey, P.D.,
Fournier, A.E., Sah, D., Cate, R., Strittmatter, S.M., Nikolov, D.B. (2003)  Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteinsEmbo J. 22, 3291-3302.
Fournier, A.E.  Takizawa, B.T., Strittmatter, S.M.  (2003) Rho Kinase inhibition enhances axonal regeneration in the injured CNSJ. Neurosci.  23, 1416-1423. 
Grados-Munro, E.M., Fournier, A.E. (2003) Myelin Associated Inhibitors of Axon Regeneration.  J. Neurosci. Res.74: 479-485.
Fournier, A.E., GrandPre, T., Gould, G.C., Wang, X., Strittmatter, S.M. (2002) Nogo and the Nogo-66 receptor.  Prog. Brain Res. 137, 361-369.

Fournier, A.E.
, Gould, G.C., Liu, B.P., Strittmatter, S.M. (2002) Truncated soluble Nogo Receptor binds Nogo-66 and blocks inhibition of axon growth by myelinJ. Neurosci.  22, 8876-8883.
Liu, B.P.,
Fournier, A.E., GrandPre, T., Strittmatter, S.M.  (2002) Myelin-associated glycoprotein as a functional ligand for the Nogo-66 receptor.  Science  297, 1132-1134.

Fournier, A.E., Strittmatter, S.M. (2002) Regenerating nerves follow the road more traveled.  Nat. Neurosci., 5, 861-867
Fournier, A.E., Strittmatter (2001) Repulsive factors and axon regeneration in the CNS.  Curr Opinion Neurobiol.  11, 89-94
Fournier, A.E., Kalb, R.G., and Strittmatter, S.M. (2000) Rho GTPases and axonal growth cone collapse. Methods Enzymol. 325:473-482.

Fournier, A.E.*, GrandPre, T.*, Strittmatter, S.M. (2000) Identification of a neuronal receptor mediating Nogo-66 inhibition of axonal regeneration.  Nature.  409, 341-346   
Fournier, A.E., Nakamura, F., Kawamoto, S., Goshima, Y., Kalb, R.G., and Strittmatter, S.M. Semaphorin 3A enhances endocytosis at sites of receptor-F-actin colocalization during growth cone collapse. (2000) J.Cell Biol. 149(2):411-421.
Wang, L.-H.,
Fournier, A.E., Nakamura, F., Takahashi, T., Kalb, R.G., and Strittmatter, S.M. Transduction of Inhibitory Signals by the axonal growth cone. In: Neurobiology of the spinal cord, edited by Kalb, R.G. and Strittmatter, S.M.Totowa, N.J.Humana Press Inc, 1999,p. 131-153.
Takahashi, T.,
Fournier, A.E., Nakamura, F., Wang, L.-H., Murakami, Y., Kalb, R.G., Fujisawa, H., and Strittmatter, S.M. (1999) Plexin-Neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99:59-69.
Lehmann, M.,
Fournier, A.E., Leclerc, N., Tigyi, G., and McKerracher, L. (1998) Inactivation of Rho signaling pathway promotes CNS axon regeneration.  J. Neurosci. 19: 7537-7547
Fournier A.E., McKerracher L. (1997) Expression of Specific Tubulin Isotypes Increases during Regeneration of Injured CNS Neurons, But Not after the Application of BrainDerived Neurotrophic Factor (BDNF) J. Neurosci.. 17: 46234632. 
Fournier A.E., Beer J., Arregui C., Essagian C., Aguayo A.J., McKerracher L. (1997).  Brain Derived Neurotrophic factor modulates GAP-43 but not Ta1 expression in injured retinal ganglion cells of adult ratsJ. Neurosci. Res.: 47 (6):561-72 .
Fournier, A.E., McKerracher, L. (1995) Tubulin expression and axonal transport in injured and regenerating neurons in the adult mammalian CNS.  Biochem. Cell Biol. 73:659-664